Progesterone: The Grinch Who Stole My Christmas

When I got my IUI I asked my doctor about progesterone supplements. I had done some research and noticed many women that had an IUI were prescribed progesterone supplements after. My doctor said she wanted me to do some blood work first do see if it was really necessary, so a blood draw was scheduled for a week later. 

Progesterone comes from the corpus luteum. Basically what happens is after you ovulate, the ruptured follicle turns into the corpus luteum which is responsible for the production of progesterone. Progesterone is an extremely important sex hormone in early pregnancy because it builds a strong uterine lining and helps maintain the lining of the uterus to help nurture a fertilized egg until the placenta takes over around the second trimester. An inadequate amount of progesterone often results in miscarriage or if there isn't a fertilized egg, your period begins. 

Hormones involved in the initiation of pregnancy and the development egg cell (ovum) from follicle to embryo.

Progesterone levels rise after ovulation, and the rise can usually be detected about a week after ovulation. According to BabyMed, progesterone levels about a week after ovulation in a nonpregnant patient are generally at least 8-10 ng/ml. Much lower levels usually mean you did not ovulate. Doctors like to see progesterone levels around 16-18 ng/ml or more in pregnant women.

Want to guess what my progesterone result came back as? 8? 6? 5? Let's try 0.46 ng/ml. This tells me two things: 
1. I didn't even ovulate, which my doctor said makes no sense because of the trigger shot I took which forces you to ovulate and my ultrasound right before my IUI appeared as if the egg had already been released.
2. I have a severe progesterone deficiency or what's also known as luteal phase defect. Super.

Looks like I have the latter and I fit right in with the symptoms, which include:
Irregular periods
Not ovulating
Fibrocystic Breasts 
Low Thyroid (Hypothyroidism -ding ding ding! Why didn't they make this connection before?)
Ovarian Cysts
Reduced oxygen levels in all cells (Perhaps this is why I feel like I'm dying when I run?) 
Anxiety
Indigestion
Headaches and more. 

Everything is interconnected. Also because I have progesterone deficiency, I have a 1000% greater chance of dying from cancer.  According to the American Journal of Epidemiology, "researchers found that infertile women who demonstrated a progesterone deficiency had a premenopausal breast cancer risk that was 540% greater than that of women whose infertility was due to non-hormonal causes. Furthermore, the women with a progesterone deficiency had a 1,000% greater chance of death from all types of cancer." Happy New Year to me. Chris hugged me all night when I told him that. I'm not worried though. I know God has a plan for me.

To finish my story, I found out about all of this the Monday before Christmas. That is why progesterone is the Grinch who stole my Christmas. My family still has no idea I'm going through all this. We were all staying at my mom's house and I locked myself in the bathroom and cried and cried and cried. The Doctor called in some progesterone supplements to the nearest pharmacy just in case of the extremely rare chance I did get pregnant. I know it wasn't going to happen though. It was all I could do to bring myself to taking a pregnancy test the following Friday since I already knew it was going to be negative. And it was. 

What kills me the most is knowing that there very well could have been a fertilized egg, but it didn't have the enough progesterone to nurture it to implantation. Every month my heart shatters into more pieces than the previous. This is hard, really hard.

I hope everyone had a wonderful Christmas and got to feel the spirit of Christ in their hearts.

Progesterone levels after ovulation (midluteal, middle of the second half of the cycle) in a nonpregnant patient are generally at least 8-10 ng/ml. Much lower levels usually mean you did not ovulate. - See more at: http://www.babymed.com/fertility-tests/progesterone-levels#sthash.ikBCoH97.dpuf

Progesterone levels rise after ovulation, and the rise can usually be detected about a week after ovulation. - See more at: http://www.babymed.com/fertility-tests/progesterone-levels#sthash.ikBCoH97.dpuf

Progesterone levels rise after ovulation, and the rise can usually be detected about a week after ovulation. - See more at: http://www.babymed.com/fertility-tests/progesterone-levels#sthash.ikBCoH97.dpuf

Progesterone levels rise after ovulation, and the rise can usually be detected about a week after ovulation. - See more at: http://www.babymed.com/fertility-tests/progesterone-levels#sthash.ikBCoH97.dpuf

Month One...No Luck

I feel so much for the couples that go through years of treatment without success. 

Their strength makes them my heros. 

Last month I had 10 straight days where I used ovulation prediction tests and every time, first thing is the morning, I received a negative. Not exactly the best way to start my day! Before I thought negative pregnancy tests felt bad, but I won't even get to the point of a pregnancy test again if I keep getting negative ovulation tests! I didn't really think this would happen since everything else was going great. When cycle day 21 came without a positive ovulation test I went in for a progesterone blood draw. (They only had to poke me once this time!) The progesterone was very low and confirmed I did not ovulate. 
So the Femara alone didn't work.

On a good note though, my hypothyroidism is under control! After 4 weeks of synthroid my thyroid is it a 2.4. Perfect! I still have some good days and bad days when it comes to my energy, but I can tell the synthroid is working. 

That was a hard week, but next month is another opportunity, so I'm keeping my chin up!

(I would like to add that our kids are going to look freaking adorable)

Timeline Update

A lot has happened since first meeting our doctor. I've been trying to play catch up since we started treatment over a month ago, but this blog is only a week old! Here's a timeline update: 

September 19th: First appointment with our fertility doctor. 

September 20th: My blood work came back and I was diagnosed with hypothyroidism. I started taking Prometrium to induce a period.

September 25th: Had further blood tests, thyroid exam (found nothing wrong) and was prescribed 50mcg of Synthroid a day. I will probably be taking it for the rest of my life. 

September 26th: Met with my gynecologist and got her up to date. Free Prenatal vitamins, yay!

October 3rd: After taking the Prometrium for 10 days my period started just three days later. 

October 5th: Went to the doctor for blood work and a follicular ultrasound. Everything looked great! Except my bladder was so full in preparation for the blood work that he couldn't see anything until I emptied it. I came back and my bladder was in the shape of a heart so he gave me an ultrasound picture for kicks and giggles. I got blood work done for an OAR, Anti-Mullerian Hormone, and TSH for my thyroid. My thyroid went down quite a bit which is great! Also my Ovarian Assessment Report came back and it was like I got straight A's! We're in the clear there. I also started taking 5mg of Femara today.

October 9th: Finished taking Femara. I didn't experience any side effects thankfully.

October 11th: The dreaded HSG! My next post will have all the details.

That's a wrap! Just keeping it positive :)